e-IDG Symposium

Spring 2023 there was another series e-IDG Symposium sessions highlighting work on illuminating understudied targets with the protein families of Ion Channels, Kinases and GPCRs as well as sharing developments of informatics and tools allowing for further exploration into these understudied areas.

IDG Digital Tool Fest - Fall 2021

IDG is hosting the first IDG DIGITAL TOOL FEST on Tuesday, November 30th with an exciting line-up of 10-minute demonstrations. The presented tools were developed within the IDG consortium covering mechanisms for exploring Drugs and their gene Targets within the context of information extracted from text-mining, expression data, and signaling pathways. The tools offer users the ability to construct their own specialized queries to access information programmatically.

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IDG e-Symposium

Spring 2021

Reactome:

Exciting news from the CEIT awardee group at Reactome. Today, June 7th, they announced the new Reactome IDG Portal: https://idg.reactome.org/ - where users can leverage Reactome's extensive pathway knowledge together with IDG’s Target Central Resource Database for numerous explorations of biochemical reactions, protein expression and biological pathways. Check it out!

Target2035:

On June 15th, the Target2035 webinar series will be highlighting "Drugging the dead – selective targeting of pseudokinases". It is a free webinar with four speakers: Patrick Eyers (University of Liverpool, IDG), Ben Major (Washington University in St. Louis, IDG), James Murphy (Walter and Eliza Hall Institute, Melbourne), Michael Lazarus (Mount Sinai School of Medicine). Please register at https://ki-se.zoom.us/webinar/register/WN_-GVR7lZ1QkWbWRwXwQmxJw.

Harmonizome

Thanks to technological advances in genomics, transcriptomics, proteomics, metabolomics, and related fields, projects that generate a large number of measurements of the properties of cells, tissues, model organisms, and patients are becoming commonplace in biomedical research. In addition, curation projects are making great progress mining biomedical literature to extract and aggregate decades worth of research findings into online databases. Such projects are generating a wealth of information that potentially can guide research toward novel biomedical discoveries and advances in healthcare. To facilitate access to and learning from biomedical Big Data, we created the Harmonizome: a collection of information about genes and proteins from 114 datasets provided by 66 online resources.

Pharos.nih.gov

Pharos is the user interface to the Knowledge Management Center (KMC) for the Illuminating the Druggable Genome (IDG) program funded by the National Institutes of Health (NIH) Common Fund. (Grant No. 1U24CA224370-01). The goal of KMC is to develop a comprehensive, integrated knowledge-base for the Druggable Genome (DG) to illuminate the uncharacterized and/or poorly annotated portion of the DG, focusing on four of the most commonly drug-targeted protein families: G-protein-coupled receptors (GPCRs); nuclear receptors (NRs); Ion Channels (ICs); and kinases.

Nucleic Acid Research Database issue features IDG digital resource: The Dark Kinase Knowledgebase

Here, we describe a data resource, the Dark Kinase Knowledgebase (DKK; https://darkkinome.org), that is specifically focused on providing data and reagents for these understudied kinases to the broader research community. Supported through NIH’s Illuminating the Druggable Genome (IDG) Program, the DKK is focused on data and knowledge generation for 162 poorly studied or ‘dark’ kinases. Types of data provided through the DKK include parallel reaction monitoring (PRM) peptides for quantitative proteomics, protein interactions, NanoBRET reagents, and kinase-specific compounds.

Nucleic Acid Research Database issue features IDG digital resource: Drugcentral.org

New additions to DrugCentral.org include a set of pharmacokinetic properties for ∼1000 drugs, and a sex-based separation of side effects, processed from FAERS (FDA Adverse Event Reporting System); as well as a drug repositioning prioritization scheme based on the market availability and intellectual property rights forFDA approved drugs. In the context of the COVID19 pandemic, we also incorporated REDIAL-2020, a machine learning platform that estimates anti-SARS-CoV-2 activities, as well as the 'drugs in news' feature offers a brief enumeration of the most interesting drugs at the present moment. The full database dump and data files are available for download from the DrugCentral web portal.