CEIT-BCM
Illuminating understudied druggable proteins using pan-cancer proteogenomics data
Professor
Lester and Sue Smith Breast Cancer Baylor College of Medicine
Professor Department of Moelcular and Human Genetics
Baylor College of Medicine
Contacts
Lab websites:
- Bing Zhang profile: https://www.bcm.edu/people-search/bing-zhang-33575
- Dr. Zhang's Lab Website: http://www.zhang-lab.org/
- Dr. Zhang's Lab Philosophy: http://www.zhang-lab.org/lab-philosophy/
Overview
Despite being the targets of 41% of approved drugs, kinases, G protein coupled receptors, and ion channels each have a number of family members about which very little is known. This project aims to integrate the recently available cancer proteogenomics data from the Clinical Proteomic Tumor Analysis Consortium (CPTAC) into the characterization of the understudied proteins in these families. Successful completion of the project will generate new computational methods and resources that can be used by the Illuminating the Druggable Genome (IDG) Consortium and the broad scientific community to generate hypotheses on the function of the understudied proteins for further experimental investigation.
NIH grant number: U01 CA271247
Publications:
- Liao Y, Savage SR, Dou Y, Shi Z, Yi X, Jiang W, Lei JT, Zhang B. A proteogenomics data-driven knowledge base of human cancer. Cell Syst. 2023 Sep 20;14(9):777-787.e5. doi: 10.1016/j.cels.2023.07.007. Epub 2023 Aug 23. PMID: 37619559; PMCID: PMC10530292 (available on 2024-09-20).