IDG News and Events
2023-05-16: e-IDG Symposium: The final session for this e-IDG Symposium series takes place on May 16, 2023. We will host Dr. Andrew White, PhD (University of Rochester) as he gives a presentation entitled "Language is the future of chemistry". To Register: https://e-idg-symposium-series-may162023.eventbrite.com |Read More|
2023-05-02: e-IDG Symposium: On May 2nd the focus for the e-IDG Symposium will be Kinases with one presentation by Dr. Caitlin Mills, PhD (Harvard School of Medicine) on "Profiling kinase inhibitor polypharmacology reveals broad coverage of dark kinases" and one presentation by Dr. Steve Angus, PhD (Indiana University School of Medicine) on "Functional kinome profiling guides therapeutic approaches for rare pediatric tumors". To Register: https://e-idg-symposium-series-may022023.eventbrite.com |Read More|
2023-04-18: e-IDG Symposium: We'll continue the e-IDG Symposium series on April 18, 2023 with presentations from 2 IDG-associated R03 awardees and learn of their illumination of Ion Channels. Dr. Samuel Young, PhD (U Iowa) give a presentation entitled "Defining the roles of CACNA2D family in regulation of synaptic function". And Dr. Harpreet Singh, PhD (OSU Medical Center) will present on "Illuminating Chloride Intracellular Channels". To Register: https://e-idg-symposium-series-apr182023.eventbrite.com |Read More|
2023-04-04: e-IDG Symposium: The spring series picks up again on April 4, 2023 with a focus on illuminating GPCRs. This session will have two presentations. Dr. Tom Helton, PhD MBA and Dr. Jeffrey DiBerto, PhD (both from Eve Bio) will present on "Focused Research Organizations and EvE: A Novel Approach to Drug Discovery". And Dr. Aashish Manglik, PhD (UCSF) will present his work on "Seeing scents: Structural insights into odorant recognition by human odorant receptors". To Register: https://e-idg-symposium-series-apr042023.eventbrite.com |Read More|
2023-02-15: e-IDG Symposium: The next session for e-IDG Symposium series takes place on February 15, 2023 with presentation by Dr. Nicolette Landsberger, PhD (Department of Medical Biotechnology and Translational Medicine, University of Milano) entitled "Identification and characterization of a new possible therapeutic target for the treatment of Rett syndrome". To Register: https://e-idg-symposium-series-feb152023.eventbrite.com |Read More|
2023-02-07: e-IDG Symposium: The Spring 2023 series of e-IDG Symposium kicks-off on February 7, 2023 with presentations on the Understudied Protein Initiative. The speakers will be Dr. Georg Kustatscher, PhD (The University of Edinburgh) and Dr. Juri Rappsilber, PhD (Technical University of Berlin and Wellcome Centre Cell Biology, Edinburgh). And they will present on the "Understudied proteins initiative - tackling annotation bias by proteomics". To Register: https://e-idg-symposium-series-feb072023.eventbrite.com |Read More|
2022-11-15: e-IDG Symposium: The final session for the Fall 2022 e-IDG Symposium series takes place Tuesday, November 15th with a focus on Informatics. We will hear from Eden Deng (Icahn School of Medicine at Mount Sinai ) on “Target identification from RNA-seq data for cell removal with immunotherapies”. And Dr. Tudor Oprea, PhD MD (Roivant Discovery ) will present “Can Humans Learn from Machine Learning in Drug Discovery?" To Register: https://e-idg-symposium-series-nov152022.eventbrite.com |Read More|
2022-11-03: e-IDG Symposium: Ion Channels are the focus for the e-IDG Symposium session on Thursday, November 3rd. Special note about the presentation time in Europe due to daylight saving time differences. This session starts at 16:00 in UK. At this session Dr. David Bennett, MB PhD, FRCP, FMedSci (The University of Oxford ) will present on “Sodium calcium exchanger-3 regulates pain ‘wind up’: human psychophysics to spinal mechanisms” and Dr. Haoxing Xu, PhD (University of Michigan ) will present on "The Acid Gate in the Lysosome"
To Register: https://e-idg-symposium-series-nov032022.eventbrite.com |Read More|
2022-10-18: e-IDG Symposium: The e-IDG Symposium session on Tuesday, October 18th will focus on GPCRs two presentations; Dr. Joshua Wollam, PhD (Escient Pharmaceuticals ) presenting on “Targeting MRGPRs: Drug Discovery Approaches and Challenges” and Dr. Julie Pickett, PhD (UNC ) presenting on "GPR97 probe development".
To Register: https://e-idg-symposium-series-oct182022.eventbrite.com/ |Read More|
2022-10-04: e-IDG Symposium: The next session of e-IDG Symposium for Fall 2022 occurs Tuesday, October 4th with the focus on Kinases with presentations from members of Lewis Cantley's lab : Dr. Jared L. Johnson, PhD, and Dr. Tomer M. Yaron, PhD. Their presentation is entitled "The Kinase Library: A substrate specificity atlas of the human kinome and its application to high throughput phosphoproteomics data".
To Register: https://e-idg-symposium-series-oct042022.eventbrite.com/ |Read More|
2022-09-20: e-IDG Symposium: The augural session for the Fall 2022 series of e-IDG Symposium takes place Tuesday, September 20th with the focus on Informatics with presentations from Dr. Andrew Leach, PhD , and Dr. Maria Paula Magarinos, PhD from SureChEMBL and ChEMBL . Their presentation is entitled "Chemical Biology Resources at the European Bioinformatics Institute: current status and some future plans".
To Register: https://e-idg-symposium-series-sept202022.eventbrite.com/ |Read More|
2022-05-17: e-IDG Symposium: The final session of this Spring 2022 Spring series of e-IDG Symposium takes place May 17th and will focus on Ion Channels with presentations from Dr. Hiro Furukawa, PhD (Cold Spring Harbor Laboratory ) on "Structures and functions of large-pore channels - case studies on CALHM and Pannexin" and from Dr. Zhaozhu Qiu, PhD (John Hopkins University ) on "From SWELL to PAC: discovery of novel chloride channels".
To Register: https://e-idg-symposium-series-may172022.eventbrite.com/ |Read More|
2022-05-03: e-IDG Symposium: Next e-IDG Symposium session will take place on May 3rd with presentations from Dr. Silvio Gutkind, PhD, ( University of California San Diego) on "Illuminating the Onco-Immune GPCRome" and from Dr. Daniel Isom, PhD ( University of Miami) on "Proton-gated coincidence detection by GPCRs".
To Register: https://e-idg-symposium-series-may032022.eventbrite.com/ |Read More|
2022-04-19: e-IDG Symposium: Our Spring series aims the light on GPCRs for this next upcoming e-IDG session on April 19th with presentations from Dr. Kathleen Caron, PhD, (University of North Carolina) on "Illuminating Orphan GPCRs in Lymphatics" and from Dr. Hongxia Ren, PhD, (Indiana University) on "Endocrine Function and Molecular Mechanisms of GPR17 Signaling in Metabolism".
To Register: https://e-idg-symposium-series-apr192022.eventbrite.com/ |Read More|
2022-04-05: e-IDG Symposium: Kinase focused e-IDG Session occurs on April 5th with presentations from Dr. Peter Sorger, PhD (Harvard) on "Measuring and modeling small molecule kinome interactions to illuminate dark kinases" and from Dr. Jarrod A. Marto, PhD (Dana-Farber Cancer Institute) on "Fragment screening for the dark kinases"
To Register: https://e-idg-symposium-series-apr052022.eventbrite.com/ |Read More|
2022-03-29: e-IDGSymposium: Kick-off session for the Spring 2022 series of e-IDG Symposium takes place on March 29,2022. Dr. Thomas Garcia, PhD from BaylorCollege of Medicine will present "The Mammalian Reproductive Genetics Database, version 2 (MRGDv2)". And Timothy Sheils and Keith Kelleher from NCATS/NIHwill showcase "Pharos: An open data resource for examining target, disease and ligand interactions"
To Register: https://e-idg-symposium-series-mar292022.eventbrite.com/ |Read More|
2021-11-30: IDG Digital Tool Fest 2021: IDG is hosting the first IDG DIGITAL TOOL FEST on Tuesday, November 30th with an exciting line-up of 10-minute demonstrations. The presented tools were developed within the IDG consortium covering mechanisms for exploring Drugs and their gene Targets within the context of information extracted from text-mining, expression data, and signaling pathways. The tools offer users the ability to construct their own specialized queries to access information programmatically. Register here:
https://hsc-unm.zoom.us/meeting/register/tJEpfuGqqTooG9DC2YjXf5ah72tBXPcOGLaS |Read More|
2021-11-18: e-IDG Symposium: Final session of this fall’s series of e-IDG Symposium occurs on November 18th, 2021 highlighting Ion Channels with presentation by Dr. Henry Colecraft, Ph.D. (Colombia) "Regulating Ion Channel Function and Expression With Engineered Nanobodies" and Dr. Markus Delling, Ph.D. (UCSF) "Illuminating the function of the dark matter polycystin channels" Register here: https://e-idg-symposium-series-nov182021.eventbrite.com/ |Read More|
2021-11-04: e-IDG Symposium: Continuation of e-IDG Symposium series will hold a session on November 4th focusing on Kinases with presentation by Dr. Jian Jin, Ph.D. (ISSMS) on "Discovery of Kinase PROTACs as Potential Cancer Therapies" and Dr. David Drewry (UNC) on "The Kinase Chemogenomic Set (KCGS): A resource for kinase vulnerability identification" Register here: https://e-idg-symposium-series-nov042021.eventbrite.com/ |Read More|
2021-10-21: e-IDG Symposium: Informatics Tools will be the focus of the e-IDG Symposium happening on October 21st, 2021. There will be talks by Anna Pamela Calinawan (Pei Wang Lab, ISSMS) "Pancancer Kinase Enrichment Analysis Provides Insights into Immunogenic Signaling Pathways"; Dr. Alexander Lachmann (Avi Ma'ayanLab, ISSMS) "PrismExp, blitzGSEA and bridgeGSEA: Incorporating Gene Function Predictions within GSEA"; and Eryk Kropiwnicki (Avi Ma'ayanLab, ISSMS) "DrugShot: Querying Biomedical Search Terms to Retrieve Prioritized Lists of Small Molecules". Register here: https://e-idg-symposium-series-oct212021.eventbrite.com/ |Read More|
2021-09-16: The e-IDG Fall 2021 series kicks off on Thursday, September 16th, 2021. It will showcase talks on kinases by invited speakers, Dr. Susan Taylor (UCSD) and Dr. Jinae Roa (UCSD), on "Retina: window into PKA signaling Neurons", and by IDG speaker, Dr. Stephan Schürer (UofMiami) on "The Dark Cancer Kinome: Untapped Opportunities to Target Understudied Kinases in Cancer". To register visit this link: https://e-idg-symposium-series-sept162021.eventbrite.com |Read More|
2021-05-18: Two IDG-associated R03 awardees will share outcomes from their IDG grants at the final session of the e-IDG Symposium Series on May 18th–Dr. Thomas Green, PhD, University of Texas Medical Branch, "GPR12 in the nucleus accumbens and addiction: electrophysiology and behavior" andDr. Daniel G. Isom, PhD, University of Miami Miller School of Medicine, "Illuminating how dark GPCRs detect protons". To register visit this link: https://idg-e-symposium-series-may182021.eventbrite.com |Read More|
2021-05-04: The 5th Session of the e-IDG Symposium Series comes with a force on May 4th with two talks on Informatics Tools – one by Dr. Paul W. Sternberg, PhD, CalTech, "Curating, integrating and presenting information about model organisms at the Alliance of Genome Resources" and one by Dr. Lincoln Stein, MD PhD, OICR and co-PI of Reactome, "Guilt by Association: A Few Tricks for Finding and Characterizing Cancer-Associated Genes". To register visit this link: https://idg-e-symposium-series-may042021.eventbrite.com |Read More|
2021-04-20: Session 4 of the e-IDG Symposium Series occurs Tuesday, April 20th, 2021 with two talks on Ion Channels by Dr. Srinivas Niranj Chandrasekaran, Broad Institute, "Accelerating drug discovery with the power of microscopy" and Dr. Stefan Feske, New York University School of Medicine, "Identification of novel ion channels and transporters in immune cells". To register visit this link: https://idg-e-symposium-series-april202021.eventbrite.com |Read More|
2021-04-06: Session 3 of the e-IDG Symposium Series occurs Tuesday, April 6th, 2021. It will showcase two talks on GPCR by invited speaker, Dr. Aashish Manglik, PhD, University of California San Francisco, "Fishing with new bait: biochemical approaches to interrogate orphan GPCR function" and and by IDG speaker, Dr. Can Cao, DRGC-GPCR, "Structural and functional study of orphan receptor". To register visit this link: https://idg-e-symposium-series-april062021.eventbrite.com |Read More|
2021-03-30: The continuation of the e-IDG Symposium Series with Session 2 will take place on Tuesday, March 30th, 2021. It will showcase two talks on kinases by Invited speaker: Dr. Martin Golkowski, University of Washington, "Targeting Phenotypic Transitions to Overcome Cancer Metastasis and Therapy Resistance" and IDG speaker: Dr. Gary Johnson, PI for DRGC-Kinase, "Plasticity of the Human Kinome Responding to Targeted Kinase Inhibition". Registration: click this link https://idg-e-symposium-series-march302021.eventbrite.com/ |Read More|
2021-03-16: The inaugural session of the e-IDG Symposium Series will take place on Tuesday, March 16th, 2021. It showcase two talks on the theme of Informatics platforms and Drug Discovery. Invited speaker: Dr. Ian Dunham, Director of Open Targets at EMBL-EBI, "Identifying and prioritising drug targets with the Open Targets Platform and Open Targets Genetics". IDG speaker: Dr. Tudor Oprea, PI for KMC and RDOC, "Illuminating the Druggable Genome: Drugs, Targets, Phenotypes and Diseases". Register here: https://idg-e-symposium-series-march162021.eventbrite.com |Read More|
Two resources produced from these efforts are: The Target Central Resource Database (TCRD) (http://juniper.health.unm.edu/tcrd/) and Pharos (https://pharos.nih.gov/), a web interface to browse the TCRD. The ultimate goal of these resources is to highlight and facilitate research into currently understudied proteins, by aggregating a multitude of data sources, and ranking targets based on the amount of data available, and presenting data in machine learning ready format. Since the 2017 release, both TCRD and Pharos have produced two major releases, which have incorporated or expanded an additional 25 data sources. Recently incorporated data types include human and viral-human protein-protein interactions, protein-disease and protein-phenotype associations, and drug-induced gene signatures, among others. These aggregated data have enabled us to generate new visualizations and content sections in Pharos, in order to empower users to find new areas of study in the druggable genome.
New additions to DrugCentral.org include a set of pharmacokinetic properties for ∼1000 drugs, and a sex-based separation of side effects, processed from FAERS (FDA Adverse Event Reporting System); as well as a drug repositioning prioritization scheme based on the market availability and intellectual property rights forFDA approved drugs. In the context of the COVID19 pandemic, we also incorporated REDIAL-2020, a machine learning platform that estimates anti-SARS-CoV-2 activities, as well as the 'drugs in news' feature offers a brief enumeration of the most interesting drugs at the present moment. The full database dump and data files are available for download from the DrugCentral web portal.
Here, we describe a data resource, the Dark Kinase Knowledgebase (DKK; https://darkkinome.org), that is specifically focused on providing data and reagents for these understudied kinases to the broader research community. Supported through NIH’s Illuminating the Druggable Genome (IDG) Program, the DKK is focused on data and knowledge generation for 162 poorly studied or ‘dark’ kinases. Types of data provided through the DKK include parallel reaction monitoring (PRM) peptides for quantitative proteomics, protein interactions, NanoBRET reagents, and kinase-specific compounds.
2020-11-30: Publication of IDG Newsletter, vol 15: link to page
2020-10-30: Publication of IDG Newsletter, vol 14: link to page
2020-10-26: ATOM-IDG Symposium Series: The goal for this outreach event is to explore collaborative activities via a joint symposium that would promote development of drugs from IDG probes. ATOM (Accelerating Therapeutics for Opportunities in Medicine) is a consortium of National Labs, Biotech/Pharma Companies and UCSF. The objective of ATOM is to transform drug discovery from experiment-driven, sequential, and high-failure to computation-driven, integrated and patient-centric. |Read More|
2020-09-30: Publication of IDG Newsletter, vol 13: link to page
2020-09-24: NIH recently announced the eight recipients of supplements via NOT-TR-20-008: Notice of Special Interest for HEAL Initiative: Request for Administrative Supplements to Existing Grants for Identification and Validation of New Pain and Opioid Use Disorder Targets within the Understudied Druggable Genome.
2020-09-10: IDG OUTREACH Meeting UNC: This symposium is aimed toward participants interested in target selection in drug discovery, expansion of protein function, development of experimental and informatics approaches to understanding proteins, as well as potential collaborators from academia, industry and not-for-profit institutes. This symposium was held virtually on Thursday, September 10th and Friday September 11th, 2020. Initially this meeting was scheduled for May 4-5, 2020. |Read More|
2020-09-01: NIH have announced the second round of IDG associated R03’s - ‘Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed)’ - RFA-RM-19-011: This time there are 17 R03 awardees. Congratulations!
2020-08-31: Publication of IDG Newsletter, vol 12: link to page
2020-07-31: Publication of IDG Newsletter, vol 11: link to page
2020-06-30: Publication of IDG Newsletter, vol 10: link to page
2020-05-29: Publication of IDG Newsletter, vol 9: link to page
2020-05-19: NIH announces a Request for Information (RFI): Input on Improvements to the Illuminating the Druggable Genome (IDG) Program’s Digital Resources - NOT-RM-20-018. The feedback requested concerning IDG’s search engine Pharos and our program’s website DruggableGenome.net. Due date for responses is July 20, 2020.
2020-04-22: NIH announces funding opportunity for ‘Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed)’ – RFA-RM-20-019. This is a reissue of RFA-RM-19-011. Application due date is July 15, 2020.
2020-04-22: Publication of IDG Newsletter, vol 8: link to page
2020-02-11: IDG held their annual consortium wide Face-to-Face meeting in Arlington, VA on February 11-12, 2020, with special invitations to the IDG associate R03 awardees.
2020-02: Publication of IDG Newsletter, vol 7: link to page
2020-01-22: KMC at UNM hosted an IDG hackathon in Albuquerque, NM on January 22-23, 2020 addressing informatics tools and methods for the IDG community and included external invitations to members of the Monarch Initiative and RCSB Protein Data Bank.
2020-01: Publication of IDG Newsletter, vol 6: link to page
2019-11-15: Finding Targets for Drug Discovery - A joint symposium hosted by Open Targets and Illuminating the Druggable Genome consortium highlighting their work to expand knowledge and experimental data to enable new targets in drug discovery.
|Read More| Registration was made via Eventbrite: see here . For a pdf of the public summary, see here.
2019-11: Publication of IDG Newsletter, vol 5: link to page
2019-10: Publication of IDG Newsletter, vol 4: link to page
2019-09: Publication of IDG Newsletter, vol 3: link to page
2019-09-01: NIH have announced 16 awardees for the IDG associated R03’s - ‘Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed)’ - RFA-RM-18-021: Congratulations! This is Round 1 of IDG associated R03 awardees.
2019-08: Publication of IDG Newsletter, vol 2: link to page
2019-07: Publication of IDG Newsletter, vol 1: link to page
2019-07-10: NIH announces funding opportunity for ‘Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed)’ – RFA-RM-19-011. This is a reissue of RFA-RM-18-021.
2019-07-01: NIH announces special funding opportunity via Administrative Supplements to Existing NIH Grant and Cooperative Agreements, ‘Notice of Special Interest (NOSI): Availability of Administrative Supplements for Enhancing Utility and Usage of Common Fund Data Sets’ – NOT-RM-19-009.
2019-05-20: NIH have announced all the awardees for the CEIT - Cutting Edge Informatics Tools for Illuminating the Druggable Genome (U01) – RFA-RM-18-011: Dr. Kannan (UGA), Dr. Robinson (JAX), Dr. Wu (OHSU). These three groups are our newest members to the IDG consortium. Congratulations!
2019-05-10: Winners are announced for the IDG-DREAM Drug Kinase Binding Prediction Challenge (www.synapse.org/drugkinasechallenge). The top performers ‘Team QED’, ‘Team AI Winter is Coming’, and ‘DMIS_DK’ will be presenting their work at the RECOMB/ISCB RSG conference - https://www.iscb.org/recomb-regsysgen2019, held Nov. 4-6, 2019 in New York City, NY.
2019-02-26: IDG held their annual Face-to-Face meeting in Arlington, VA on February 26-27, 2019. Here is a link to the public summary for this meeting: link to pdf.
2018-12-10: PLOS Biology Commentary from IDG PI’s, https://doi.org/10.1371/journal.pbio.3000067
2018-11-15: Deadline for Round 1 of IDG-DREAM Drug Kinase Binding Prediction Challenge https://www.synapse.org/#!Synapse:syn15667962/wiki/583305
2018-11-07: Dr. Bryan Roth gave the Presidential Special Lecture entitled "From Salvia Divinorum to LSD: Toward a Molecular Understanding of Psychoactive Drug Actions" at the annual meeting for Society for Neurosciences in San Diego, CA on Nov 7 2018 – link: https://www.sfn.org/Meetings/Neuroscience-2018/Sessions-and-Events/Scientific-Program/Lectures
2018-10-24: NIH announces funding opportunities via two different mechanisms: SBIR: ‘Commercializing Understudied Proteins from the Illuminating the Druggable Genome Project (IDG) (R43/R44 Clinical Trial Not Allowed)’ – PA-19-034 and STTR: ‘Commercializing Understudied Proteins from the Illuminating the Druggable Genome Project (IDG) (R41/R42 Clinical Trial Not Allowed)’ – PA-19-033.
2018-10-16: BIOINFORMATICS BOOTCAMP: INFORMATICS IN DISEASE BIOLOGY AND DRUG DISCOVERY, Tuesday, October 16 - 4:30-6:30pm. Hands-on worskhop to access, visualize and analyse IDG-specific data requires additional registration fee and there will be a limited number of attendees (NAVBO2018) Newport, RI – link to information site
2018-10-01: Launch of IDG-DREAM Drug Kinase Binding Prediction Challenge (https://www.synapse.org/#!Synapse:syn15667962/wiki/583305), with press release from FIMM (https://www.fimm.fi/en/news/1538461918)
2018-08-23: IDG Outreach meeting with BAGIM (Boston Area Group for Informatics and Modeling) at Harvard University, covering presentation from IDG members. |Read More|
2018-08-22: Symposium entitled “Move Away from the Lamppost & Find Druggable Targets” at ACS Fall 2018 National Meeting in Boston, MA, organized by Tudor Oprea and Rajarshi Guha |Read More|
2018-07-20: NIH announces funding opportunity for ‘Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed)’ - RFA-RM-18-021.
2018-03-13: IDG Consortium Kick-off meeting was held on NIH Campus in the Natcher Building on March 13-14, 2018. The full IDG consortium, at this time, includes:
- 3 DRGC awardees: GPCR focused: Dr. Roth (UNC), Kinase focused: Dr. Johnson (UNC), Ion Channel focused: Dr. McManus (UCSF)
- 2 KMC awardees: Dr. Ma’ayan (ISMMS), Dr. Oprea (UNM)
- 1 RDOC awardee: Dr. Schürer (UMiami)
2018-02-03: Dr. Rajarshi Guha, (KMC-NCATS), presented as an 2018 SLAS finalist with a talk entitled "Pharos – A Torch to Use in Your Journey In the Dark Genome" at 2018 Annual SLAS meeting in San Diego, CA Feb 3-7, 2018. - link to information site