Knowledge Management Center for Illuminating the Druggable Genome

Contacts

• Email: sorin_avram@acad-icht.tm.edu.ro
• ICTRA Research page: https://acad-icht.tm.edu.ro/wp/eng/
• Research gate: https://www.researchgate.net/profile/Sorin_Avram

Overview

Dr. Sorin Avram utilizes his background in pharmaceutical sciences together with programming skills to solve simple to complex problems including linking targets/genes to diseases/phenotypes. In addition his team collects data focusing on FDA new approved drugs, then integrates and organizes these into the existent database (e.g., DrugCentral), thereby verify and standardizing the pharmacological and regulatory information for active pharmaceutical ingredients and products from high standards resources. His team includes Dr. Ramona Curpan, Dr. Liliana Halip, and Dr. Alina Bora.

NIH grant number: 1U24 CA224370-01

KMC-ICTRA publications:

1. Halip L, Avram S, Curpan R, Borota A, Bora A, Bologa C, Oprea TI. Exploring DrugCentral: from molecular structures to clinical effects. J Comput Aided Mol Des. 2023, doi: 10.1007/s10822-023-00529-x.

2. Avram S, Wilson TB, Curpan R, Halip L, Borota A, Bora A, Bologa CG, Holmes J, Knockel J, Yang JJ, Oprea TI. DrugCentral 2023 extends human clinical data and integrates veterinary drugs. Nucleic Acids Res. 2023, 51(D1):D1276-D1287. doi: 10.1093/nar/gkac1085.

3. Avram S, Halip L, Curpan R, Oprea TI. Novel drug targets in 2022. Nat Rev Drug Discov. 2023, 22:437. doi: 10.1038/d41573-023-00068-y.

4. Avram S, Halip L, Curpan R, Oprea TI. Novel drug targets in 2021. Nat Rev Drug Discov. 2022, 21(5):328. doi: 10.1038/d41573-022-00057-7.

5. Avram S, Curpan R, Oprea TI (2022) Book Title: Drug Repurposing, Edited by David Cavalla, Publisher The Royal Society of Chemistry (www.rsc.org), Drug Discovery Series 82, ISBN 978-1-78801-903-3, ISSN 2041-3211,  Chapter 7 Cheminformatics Data Mining and Modeling for Drug Repurposing. pages 129-146

6. Avram S, Halip L, Curpan R, Borota A, Bora A, Oprea TI. Annotating off-label drug usage from unconventional sources. medRxiv. 2022, doi: 10.1101/2022.09.08.22279709

7. Avram S, Halip L, Curpan R, Oprea TI. Novel drug targets in 2020. Nat Rev Drug Discov. 2021 May;20(5):333. doi: 10.1038/d41573-021-00057-z.

8. Avram S, Bologa CG, Holmes J, Bocci G, Wilson TB, Nguyen DT, Curpan R, Halip L, Bora A, Yang JJ, Knockel J, Sirimulla S, Ursu O, Oprea TI. DrugCentral 2021 supports drug discovery and repositioning. Nucleic Acids Res. 2021 Jan 8;49(D1):D1160-D1169. doi: 10.1093/nar/gkaa997.

9. Avram S, Curpan R, Halip L, Bora A, Oprea TI. Off-Patent Drug Repositioning. J Chem Inf Model. 2020 Dec 28;60(12):5746-5753. doi: 10.1021/acs.jcim.0c00826.

10. Avram S, Halip L, Curpan R, Oprea TI. Novel drug targets in 2019. Nat Rev Drug Discov. 2020 May;19(5):300. doi: 10.1038/d41573-020-00052-w.